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Kinin–kallikrein system
The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research. It consists of blood proteins that play a role in inflammation, blood pressure control, coagulation and pain. Its important mediators bradykinin and kallidin are vasodilators and act on many cell types.
==History==
The system was discovered in 1909 (Abelous & Bardier) when researchers discovered that injection with urine (high in kinins) led to hypotension (low blood pressure). The researchers Emil Karl Frey, Heinrich Kraut and Eugen Werle discovered high-molecular weight kininogen in urine around 1930.
Etymology: kinin () kīn(eîn) to move, set in motion. kallikrein () kalli~ sweet and krein = kreos, flesh, named for the pancreatic extracts where it was first discovered
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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